nicole @nicole@myna.social

Seeing family today? Want an excuse to get away from that for a little bit? Ask if they'd mind if you made their internet experience better.

If they say yes, go to their computer, and then download and install #firefox. Migrate their data from their default browser, and then set #firefox as the default. They'll be thankful!

And if they're already a #firefox user, then tell them Mike Conley (a stranger on the internet) is thankful for that. :)

@Em0nM4stodon Ahh, emoji, the modern Esperanto.

Nap time in the sun. 🫏

A little disappointed the armed guards at the ferry terminal didn’t flag me for a bag check.

https://mozilla.social/discover list is just cool thing to go to for the quite time at the end of the day instead of all other places I used to go to ...

Someone was snickering about "pregnant person", and I as like. Dude. We use inclusive language all the time in math. There's literally an infinite number of positive numbers, and yet we still use "non-negatives", because we specifically want to include zero. It's the same fucking thing.

AT&T Long Lines Oak Hill Tower, San Jose, CA 2021.

This unusual Brutalist tower was part of the former AT&T terrestrial microwave network that once carried the bulk of US long distance telephone traffic. The (long since disconnected) horn antennas are too big and heavy to remove.

Too many pixels at https://www.flickr.com/photos/mattblaze/51261791084

#photography

@nicole@myna.social It’s funny. I’m one of those people who has incredible difficulty naming their own feelings, but anything involving harm to an animal triggers immediate and overwhelming emotions with perfect clarity.

I have strong anecdotal evidence that the same was true for my maternal uncles and grandfather.

It’s always been like this for me, but I feel like HRT dialed it up another couple of notches to the point of near absurdity.

Is crying on demand a useful party trick?

Here's what I did with my weekend. Still some finishing to do tomorrow, but it's coming together.

I'm really pleased with how the laser etching came out on the sleeves and shoulders (it took a lot of work, please clap).

#StarTrek #StarTrekSNW #StarTrekCostume #StarTrekCosplay

TIL I need to recalibrate my JPY to USD heuristic. I’ve been using 100:1 for 30 years, but I knew the Japanese economy has been sluggish for at least that long.

The conversion today is 150:1.

Has anyone tried the new Activity Pub plugin for Wordpress?

It’s out of beta now.

I have a Wordpress site (which I need as an author) and a Mastodon instance (which I need because I am a control freak).

If Activity Pub works as it should, I won’t need both — but we can’t get Activity Pub to work on a Wordpress site.

Has anyone tried this?

I will trade legal analysis for technical help. (Fediverse economics)

It’s October, so I’m squirreled up with a small press collection of creepy stories, The Faces at Your Shoulder.

The first story turns out to be an even more-Lovecraftian spin on Campbell’s Who Goes There? (i.e., The Thing). It’s set at the tail end of the Gold Rush, but, other than its setting, it’s derivative as all get-out.

Doesn’t matter: the literary equivalent of a Spooky Sounds CD is exactly what I was looking for. 🎃

Starting to feel the itch to go home again. #fromthearchives #tucson

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944393/

This is most absurd clinical findings ive seen regarding trans females. It states they prescribed "oral estradiol" starting at 2mg and increasing in dose over a year to try and achieve levels above 100 pg/ml with an aim towards monotherapy between 2008 and 2018 looking at 184 trans women in their clinic.

Looking at their scatter chart they state 1 patient achieved about 90 pg/ml on 1mg oral, 2 patients achieved over 100 pg/ml on 2mg oral, and 21 achieved over 100 pg/ml on 4 mg oral.

For these results to be at all useful in terms of monotherapy they need to have been done at trough level (ie 24 hours after the last dose) as you need to keep your estradiol level above a set amount to manage such a feat.

The issue? a patient on 1mg oral will not see estradiol levels above 25 pg/ml at peak, a patient on 2mg oral will not see estradiol levels above 50 pg/ml at peak, and 4mg oral will only break 100 pg/ml at peak at 6-8 hours and then crash below 40 pg/ml after 24 hours.

So whats going on? well a minority of their patients who somehow magically achieved the impossible, as usual were doing what trans girls in the US do all the time, they take the medication they're given and then took it sublingually (and likely broke up their doses through the day) because you get far higher levels that last longer that way.

The only other explanation is these patients had their estradiol levels tested incorrectly either not at trough or there was an aberration in the test.